David Mitchell is best known as one half of comedy partnership, Mitchell and Webb. The pair met at Cambridge, where Mitchell was president of the Cambridge Footlights. Together they have written and starred in several sketch shows for radio and television; The Mitchell & Webb Situation, That Mitchell & Webb Sound and That Mitchell & Webb Look. Together, they are most famous for the Channel 4 sitcom, Peep Show. They both appeared in the film Magicians, in which Mitchell played traditional magician Harry.
Mitchell and Webb received the Best Comedy Award at the Variety Club Showbiz awards 2008.

On his own, Mitchell has had parts in BBC's Jam & Jerusalem and the ShakespeaRe-told adaptation of The Taming of the Shrew. He is a frequent participant on British panel shows, including QI, Mock the Week and Have I Got News For You. He is host of The Unbelievable Truth. 

The Radio Times named him 'The Best Comedy Panel Show Guest' in the world, stating that 'he's incredibly, disgustingly witty' and 'even starting to make Paul Merton look slow on the uptake'. He cites Spike Milligan, Peter Sellers and Peter Cook as his comedy idols.

Awards
In 2009, Mitchell won the British Academy Television Award for Best Comedy Performance for his work on Peep Show, after having lost in the same category the year before. 

He won the award "Best Television Comedy Actor" at the 2007 British Comedy Awards, and the pair shared the 2007 Royal Television Society Award for "Comedy Performance". They were also jointly nominated for "Best Television Comedy Actor" at the 2006 British Comedy Awards. 

Peep Show itself has also won the BAFTA for "Best situation comedy" in 2008, and the British Comedy Award for "Best TV comedy" in 2006, and retained it the following year. It also won "Best TV Comedy" at the South Bank Show Awards, and claimed a Golden Rose in 2004.